Plain meaning
Start with the shortest useful explanation before going deeper.
A Solana program whose upgrade authority has been set to None, permanently preventing any future bytecode changes. Once a program is made immutable, its on-chain code can never be modified, providing the strongest guarantee to users that the program logic they interact with will not change. Immutability is achieved by invoking the Upgradeable BPF Loader's SetAuthority instruction with None. This is irreversible and should only be done after thorough auditing and testing.