Plain meaning
Start with the shortest useful explanation before going deeper.
A byte ordering convention where the least significant byte is stored at the lowest memory address. Solana uses little-endian byte order for all on-chain data serialization (Borsh defaults to little-endian), matching the native byte order of x86/ARM CPUs that run validators. When manually reading or writing multi-byte integers from account data, developers must use little-endian functions (e.g., u64::from_le_bytes in Rust, readUInt32LE in Node.js).